A motorcyclist suffered a fall between Oberfeulen and Mertzig at 9.45pm, suffering injuries in the process.
Two people were later injured in a car collision between Esch-sur-Alzette and Belvaux. Emergency medical services were also on the scene.
At 10.30pm, one person was injured in an accident involving a car and a motorcycle between Abweiler and Leudelange.
