It is unclear what the trailer was carrying, but cargo could be seen scattered across the road.
The exit has been closed, as is the N32 between the Woeller and Gadderscheier roundabout.
Emergency services also reported four injuries in four separate accidents on Tuesday afternoon.
A car and motorcycle collided at the Raemerich roundabout in Esch around 5pm. One person was injured.
Emergency services were called to another motorcycle accident in Rue du Cimetière in Bonnevoie. Shortly before 6pm, a motorcyclist was left with injuries after falling off their bike.
Two cars collided on Avenue Frantz-Clement in Mondorf-les-Bains at 6pm. One person was injured. An ambulance from Remich, as well as firefighters from Remich and Mondorf were on site.
A motorist was injured after crashing into a tree on the CR306 between Bissen and Pettingen. A first responder from Ettelbruck was dispatched, as well as other emergency services from the area.
