The woman, who was alone in one of the vehicles, could not be saved. She died at the site of the accident.
The driver in the other car was admitted to hospital with serious injuries.
The forensic police were despatched to the scene to shed light on this head-on collision with tragic consequences.
The road was closed to traffic until late at night and only reopened around 2am.
The fire fighters from Kehlen and Mamer as well as the first responder (Samu) and the ambulances from Mamer and Luxembourg City were on site.