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The F91 Dudelange team will face the Spanish football team at 9pm on Thursday evening in Luxembourg City's Josy Barthel stadium in the club's last Europa League match this year.
In their first match against Real Betis, Luxembourg trainer Dino Toppmöller's team was at the top of their game for the most part.
Nevertheless, F91 Dudelange ended on the end of a stinging defeat, losing 3-0.
Thursday evening's match will be streamed live on RTL.lu (RTL's main online site, in Luxembourgish).
Several road closures
Some streets around Josy Barthel stadium will be closed for a couple of hours on Thursday: Rue des Foyers, Boulevard Napoléon 1er and Rue du Stade will be blocked between 4pm and midnight.
Route d'Arlon between Square New York and Rue des Aubépines, Rue des Arquebusiers, Rue Aloyse Kayser, Rue Ostende and Rue Nicolas Simmer will be partially closed during the same period of time.