The Red Cross is currently providing housing for 1,500 people, but says this is insufficient to meet the need.
In a press release, the charity appealed to property owners who are willing to rent out their apartment.
Owners would have the option of doing this through the social rental management programme, or through a regular rental contract with the Red Cross acting as guarantor.
The charity is looking for all types of accommodation across the country, with contracts ideally lasting at least a year.
When hundreds of refugees from Ukraine arrived in the Grand Duchy earlier this year, Luxembourg residents showed remarkable solidarity efforts, says Nadine Conrady of the Red Cross.
Now, however, the situation remains precarious, yet the Red Cross' accommodation is at capacity. Conrady hopes that people will come forward to prevent those in difficult financial situations from becoming homeless.