The cheeky new series has Markle, seen following her 2017 engagement to Prince Harry, bombarding fictional Pope John Paul III, played by John Malkovich, with demands for fashion advice / © AFP/File
She is already at war with the Queen -- now the "Pope" is turning on Meghan Markle.
The Duchess of Sussex is the butt of a string of catty quips in the new television series, "The New Pope", which premieres on HBO and Sky Atlantic Monday.
The timing of the show -- the follow-up to "The Young Pope" -- could not be worse for the American actress, whose bombshell announcement that she and Prince Harry were stepping back from frontline royal duties has rocked the British monarchy.
The cheeky smash-hit Vatican drama that saw Jude Law's dishy American pope struck down by a heart attack in the first series, has Markle bombarding his replacement with demands for fashion advice in the second.
Gladhanding admirers and greeting babies is one thing for a papal Malkovich -- but repeatedly giving fashion advice to royals is rather a "nuisance," according to "The New Pope" script / © AFP/File
"What a nuisance!" barks the fictional Pope John Paul III played by Hollywood star John Malkovich as his butler fields another call supposedly from Markle.
"Wear the yellow Dior because it plays up the contrasts with your complexion," Sir John Brannox, the aristocratic English prelate played by Malkovich tells Markle in one scene.
"No, Meghan I am adamant, wear the yellow," he adds.
"She calls me 25 times a day for beauty tips. She thinks I'm gay," he later confesses to the Vatican's spin doctor.
- Lack of class -
While Markle -- who wore Dior for the baptism of son Archie in July -- does not appear herself, she is a recurring presence in the series' early episodes.
"They want to be influencers but they have no idea of colour combinations," Malkovich's character adds in one of many takedowns aimed at Markle, who has complained about being persecuted by the British tabloid press.
Her husband has branded some of the criticism of the mixed-race former "Suits" star as racist.
In the series, Brannox is voted pope after Law's immediate replacement, Pope Francis II, dies in mysterious circumstances after threatening to give away all the Church's riches.
"What will Meghan do without me?" Malkovich sighs after he finally agrees to be pontiff.
Born-again: British actor Jude Law (left) who plays the "ressurected" pontiff in "The New Pope" with Paolo Sorrentino at the Venice film festival in September / © AFP/File
The American actress -- whose feminism and social media savvy has made her an uncomfortable fit for the British royals -- is the target of a further jibe about her supposed lack of breeding in the show.
Its award-winning Italian director Paolo Sorrentino insisted he "has nothing against Meghan. But to make people laugh I am ready to detest anyone."
Despite its gags at the expense of Markle, "The New Pope" -- which also features a "resurrected" Law -- is being billed for its feminist take on the machinations inside the Catholic church.
- Nuns on strike -
As well as a teasing trailer that featured Law's pope walking along the beach in a pair of skimpy white swimming trunks, it has the Vatican's nuns go on strike and actresses Cecile de France and Ludivine Sagnier in key roles.
John Malkovich, dressed in papal garb, lifts a baby during filming last year of "The new Pope" in Rome / © AFP/File
"The Church is much more sexist than the rest of the world," Sorrentino told AFP.
"Women absolutely do not have the same rights; they cannot say Mass, they live according to how men want them to. This is a situation that will end," added maker of the Bafta-winning film "La Grande Bellezza".
Sorrentino said that far from being shocked by the sex, corruption and constant back-stabbing that the series portrays, Vatican insiders seemed to enjoy it.
He insisted that there was nothing in it that would shock priests "who are listening to sins all day long in the confessional boxes."
When he visited the Vatican, "clerics were smiling and winking at me, as if to say they liked it," the Italian added.
The series comes at a time of unprecedented interest by Hollywood in the inner workings of the Catholic church, with Jonathan Pryce nominated for an Oscar on Monday for his performance as the real Pope Francis in Netflix's "The Two Popes".